KSBNS 2024
in conjunction with the APSN
October 15(Tue)-18(Fri), 2024
HICO, Gyeongju, South Korea
October 15(Tue)-18(Fri), 2024
HICO, Gyeongju, South Korea
Jinsoo Seo / Daegu Gyeongbuk Institute of Science and Technology
ModeratorJinsoo Seo / Daegu Gyeongbuk Institute of Science and Technology
Our brain interacts with other tissues, which can regulate and alter the brain's functions. Recent studies reveal that changes in the environment around the brain (such as blood vessels and guts) are closely linked to the onset and progression of Alzheimer's disease. In this symposium, we aim to discuss the latest research findings from distinguished speakers and explore how these discoveries could lead to the development of effective treatments.
Speaker | Affiliation | Title |
---|---|---|
Joel Blanchard | Icahn School of Medicine at Mount Sinai | Modeling the interactions of diet and genetics with in vitro models of the human brain |
Inhee Mook-Jung | Seoul National University | The role of gut-vagus nerve-brain axis in Alzheimer's disease pathogenesis |
Soochul Park | Sookmyung Women's University | Cerebrovascular clearance of neurotoxic substances and Alzheimer's disease |
Jong-Woo Sohn / Korea Advanced Institute of Science and Technology
ModeratorHyung Jin Choi / Seoul National University
Brain and body communicate and work together to maintain homeostasis, which is the state of equilibrium or balance in the internal environment of our body. In particular, the hypothalamus and the brainstem are responsible for coordinating the activity of all the body’s systems, which includes endocrine organs, digestive tract, skeletal muscle and even microbiome to secure homeostasis. In this symposium, there will be cutting-edge researchers on bi-directional communication between brain and peripheral organs.
Speaker | Affiliation | Title |
---|---|---|
Ivan de Araujo | Max Planck Institute for Biological Cybergenetics | Parallel circuitries that connect body and brain |
Joe Eun Son | Kyungpook National University | Hypothalamic function of IRX3 and IRX5, genetic determinants of human obesity |
Kevin W. Williams | University of Texas Southwestern Medical Center | Effects of metabolic state on the regulation of melanocortin neurons |
Min-Seon Kim | University of Ulsan | Regulation of skeletal muscle mass and strength by hypothalamic neurons |
Jee Hyun Choi / Korea Institute of Science and Technology
Hye-Young Shin / Seoul National University
ModeratorJee Hyun Choi / Korea Institute of Science and Technology
This symposium is dedicated to improving our understanding of transient oscillations in the beta and gamma frequency bands, which are increasingly recognised as crucial for interpreting the neural mechanisms of cognition and behaviour. The aim is to further explore the underlying neural mechanisms associated with these cognitive processes and to identify new avenues of research. The agenda includes an examination of the role of beta bursts in predictive coding, the interplay between beta and gamma bursts in cognitive functioning, the neural circuitry underlying beta and gamma bursts, and the clinical implications that these bursts may have. It is expected that the symposium will act as a conduit for the exchange of the latest research on beta and gamma bursts and their role in higher-level cognitive processing, encompassing studies in mice, monkeys and humans.
Speaker | Affiliation | Title |
---|---|---|
Andre Bastos | Vanderbilt University | Multi-Area, high-Density, Laminar Neurophysiology (MaDeLaNe) recordings suggest Predictive Coding is implemented via Predictive Routing |
Hyeyoung Shin | Seoul National University | Transient spectral events: mechanisms and meaning |
Hio-Been Han | Massachusetts Institute of Technology | Theta long-range synchrony in the cerebral cortex in support of perception and action |
Greg Seong-Bae Suh / Korea Advanced Institute of Science and Technology
ModeratorGreg Seong-Bae Suh / Korea Advanced Institute of Science and Technology
Humans and many other organisms use their five senses to gather the physicial and chemical information from the external world. The noceiceptive system and its associated touch, itch and pain sensations rely not only on the external senses, but require interceptive sensing. This symposium will explore recent advances in our understanding of mammalian somatosensation that highlight the use of cutting-edge technologies and reveal novel mechanisms involved genes, neural circuits and behavior. We will also reserve time for a short talk that represents another type of interoceptive sensing in animal. Our goal is to encourage the sharing unpublished data, promote lively discussions and foster new collaborations across the field.
Speaker | Affiliation | Title |
---|---|---|
Zhou-Feng Chen | Shenzhen Bay Laboratory | The coding logic of itch, pain and touch |
Hyosang Lee | Daegu Gyeongbuk Institute of Science and Technology | The role of Twik-1 in somatic sensation and neuropathic pain |
Wenbiao Gan | Peking University | Clear optically matched panoramic access channel technique (COMPACT) for large-volume deep brain imaging to study nerve injury and inflammatio |
Chun Kee Chung / Seoul National University
ModeratorChun Kee Chung / Seoul National University
Communication, crucial for human interaction, encompasses two key aspects: perception and production. This symposium delves into the advanced Brain-Computer Interface (BCI) technology, focusing on neural mechanisms underlying these processes and state-of-the-art deep learning architectures. This symposium deals with crucial challenges such as intelligibility, controllability based on speech processing in human brain. We expect this symposium will provide insights into innovative frameworks and applications revolutionizing the field of speech BCI. Appealing to a diverse audience interested in the intersection of technology and science, this symposium bridges pioneering electrodes recording neural activities, brain stimulation to evoke perception, and BCIs to reconstruct one’s intention.
Speaker | Affiliation | Title |
---|---|---|
Sunggu Yang | Incheon National University | Exploring the Functional Organization and Neural Dynamics of the Motor Cortex Using wireless neural interface in Rhesus Monkeys |
Sung-Phil Kim | Ulsan National Institute of Science and Technology | Spatiotemporal electrocorticographic patterns during brain stimulation-induced auditory perception |
Chang-Hwan Im | Hanyang University | Deep learning methods for speech recognition from neural signals |
Hong-Goo Kang | Yonsei University | Neural speech synthesis from electrical bio-signals |
Han Kyoung Choe / Daegu Gyeongbuk Institute of Science and Technology
ModeratorHan Kyoung Choe / Daegu Gyeongbuk Institute of Science and Technology
The neuroimmune interaction emerges as a key player in regulating the physiology and pathology of the brain as well as controlling immune functions. The crosstalk between the nervous system and the immune system embraces multiple types of organs, tissues, and cells, requiring comprehensive investigation at multiple levels. To facilitate understanding of current advances in neuroimmune interaction, we aim to collect leading scientists focusing on each critical player - traditional immune system, brain-blood barrier, glial cells, and even brain-resident immune cells. This session will provide a comprehensive introduction and discussion of the diverse types of neuroimmune interaction and their physiological and pathological consequences, with the hope of incubating international collaboration.
Speaker | Affiliation | Title |
---|---|---|
Yeong Shin Yim | The University of Pennsylvania | Immune-regulatory network in the brain |
Eunha Kim | Korea University | Exploring mmune-microbiome-brain axis in a neurodevelopmental disorder mouse model |
Won-Suk Chung | Korea Advanced Institute of Science and Technology | Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis |
Do-Geun Kim | Korea Brain Research Institute | Pathological roles of blood brain barrier dysfunction in the development of neurodegenerative diseases |
Chul Hoon Kim / Yonsei University
ChangHui Pak / University of Massachusetts Amherst
ModeratorChul Hoon Kim / Yonsei University
In the past decade, human pluripotent stem cell derived 3D neural organoids have become invaluable tools for modeling early developmental processes and central nervous system disorders. As neuropsychiatric and neurodegenerative disorders are shaped by underlying complex human genetic backgrounds which ultimately modify the disease risk, onset, and progression, human induced pluripotent stem cells (hiPSCs) grants direct access to unique human genetic backgrounds for experimental exploration. This symposium aims to showcase ongoing research by early-stage investigators who have utilized 3D neural organoid models to gain insights into the complexities of brain disorders and neurodevelopment. By focusing on the intersection of advanced cellular models and complex genetic influences, the speakers will present recent findings contributing to our understanding of translational research.
Speaker | Affiliation | Title |
---|---|---|
ChangHui Pak | University of Massachusetts Amherst | Unveiling disease-specific impacts of NRXN1 deletions on cortical synaptic function and plasticity using human iPSC-derived neural cells |
Ki-Jun Yoon | Korea Advanced Institute of Science and Technology | SLTM regulates Neurogenic-Gliogenic Switch in Human Brain Organoid Models of Neurodevelopmental Disorders |
Jinsoo Seo | Daegu Gyeongbuk Institute of Science and Technology | Early cellular changes in neurons linked to presymptomatic Alzheimer's disease |
Sang Ah Lee / Seoul National University
ModeratorSang Ah Lee / Seoul National University
Inah Lee / Seoul National University
The critical role of the hippocampus in spatial and episodic memory has been documented across many species across the phylogenetic tree. While the field has benefited immensely from the wide range of studies on hippocampal function, it still remains a challenge to bring together unique insights from each species into a comprehensive understanding of how episodic memory works. In this symposium, expert neuroscientists in the field of memory research across rodents, non-human primates, and humans will share their recent findings on hippocampal processes measured at the level of single neurons, brain oscillations, and functional neuroimaging. In discussing both common and unique characteristics of spatial and episodic memory across multiple species, we hope to provide a fresh perspective on how such evolutionarily ancient neural mechanisms give rise to our daily experience of episodic memory. By bridging research across subfields of behavioral and cognitive neuroscience, this symposium will interest researchers from various areas of neuroscience and the broad KSBNS community.
Speaker | Affiliation | Title |
---|---|---|
Inah Lee | Seoul National University | Hippocampal correlates of contextual object recognition memory in nonhuman primates |
Sebastien Royer | Korea Institute of Science and Technology | Memory trace of a butterfly encounter |
Joshua Jacobs | Columbia University | Probing the neural basis of human memory with direct recordings of place and grid cells and traveling waves |
Sang Ah Lee | Seoul National University | Constructing memories across space and time in human episodic memory |
Heejung Chun / Yonsei University
Tae-In Kam / Korea Advanced Institute of Science and Technology
ModeratorHeejung Chun / Yonsei University
Tae-In Kam / Korea Advanced Institute of Science and Technology
Astrocytes play multiple and essential roles in brain function. In response to various pathological stimuli, reactive astrocytes exhibit molecular, structural and functional alterations and play an important role in the pathogenesis of neurological disorders. Reactive astrocytes lose their homeostatic function and have beneficial and/or detrimental effects on disease progression. Although in vivo research ranging from molecular and cellular levels to behavioral levels are challenging, research into the relevant mechanisms and diagnosis of neurological disorders through reactive astrocytes is actively ongoing. This symposium will in-depth discuss the role of reactive astrocytes and diagnostic/therapeutic strategies for treating neurological disorders and will shed light on the enigmatic roles and mechanisms of astrocytes in the brain.
Speaker | Affiliation | Title |
---|---|---|
Min-Ho Nam | Korea Institute of Science and Technology | Tonic excitation by astrocytic GABA causes neuropathic pain through augmenting neuronal activity and glucose metabolism |
Tae-In Kam | Korea Advanced Institute of Science and Technology | Role of neurotoxic reactive astrocytes in Lewy body dementia |
Heejung Chun | Yonsei University | 18F-THK5351, a PET tracer for imaging MAO-B-mediated reactive astrocytes in Alzheimer’s disease |
Nobuyuki Okamura | Tohoku Medical and Pharmaceutical University | 18F-SMBT-1 PET imaging of reactive astrogliosis in neurodegenerative diseases |
Kwok-On Lai / City University of Hong Kong
ModeratorKwok-On Lai / City University of Hong Kong
In this symposium, four international speakers will share their recent findings that provide new insights into RBP functions in neurons. Sourav Banerjee (National Brain Research Centre of India) will discuss a novel way to regulate local mRNA translation via FUS and long non-coding RNAs (lncRNAs) at the synapse and its role in learning and memory. Che-Kun James Shen (Academia Sinica, Taiwan) will present a new role and mechanism of TDP-43 in pre-mRNA splicing in a transgenic mouse model of ALS. Nobuyuki Shiina (National Institutes of Natural Sciences) will describe an unconventional mechanism by which FUS and TDP-43 control local translation during synapse formation. Kwok-On Lai (City University of Hong Kong) will discuss a strategy that involves transplantation of human induced pluripotent stem cells (hiPSC) to demonstrate how chronic behavioural stress interacts with ALS-related FUS gene mutation to aggravate the disease phenotypes of human neurons in vivo.
Speaker | Affiliation | Title |
---|---|---|
Sourav Banerjee | National Brain Research Centre | Synapse-enriched long non-coding RNAs regulates fear memory formation involving dendritic protein synthesis |
James C.-K. Shen | Taipei Medical University | RNA mis-metabolism and pathogenesis of a mouse model of amyotrophic lateral sclerosis (ALS) carrying mutation in the RNA-binding and ALS-associated protein TDP-43 |
Nobuyuki Shiina | National Institutes of Natural Sciences | Impact of pathogenic FUS and TDP-43 on RNG105/caprin1 dynamics in RNA granules: Implications for synaptic loss in neurons |
Kwok-On Lai | City University of Hong Kong | Neuronal functions of the two RNA-binding proteins G3BP1 and FUS in heath and disease: beyond the formation of stress granules |
Soo-Jin Oh / Korea Institute of Science and Technology
Uhtaek Oh / Korea Institute of Science and Technology
ModeratorSoo-Jin Oh / Korea Institute of Science and Technology
Uhtaek Oh / Korea Institute of Science and Technology
Mechanobiology in the nervous system explores how mechanical forces influence the structure, function, and development of neural tissues. This symposium delves into the intricate relationship between mechanical cues/stimuli and neuronal/glial processes, from molecular and cellular responses to tissue-level organization. Experts will discuss topics such as mechanotransduction primarily mediated by mechanosensitive ion channels in brain cells and the impact of biomechanical forces on signal transduction and cellular homeostasis. Cutting-edge research will unravel the fascinating interplay between mechanics and neurobiology and broaden our understanding of the complexity and resilience of the nervous system.
Speaker | Affiliation | Title |
---|---|---|
Uhtaek Oh | Korea Institute of Science and Technology | Tentonins, mechanosensitive channels and their functions |
Bailong Xiao | Tsinghua University | An intermediate open structure reveals the curvature-based gating of PIEZO1 |
Soo-Jin Oh | Korea Institute of Science and Technology | Tweety-homolog (TTYH) family encodes volume regulating anion channel |
Bo-Eun Yoon | Dankook University | Carbon nanotube platform regulating intracellular calcium and physiological functions of astrocytes differentially across brain regions |
June-Seek Choi / Korea University
ModeratorJune-Seek Choi / Korea University
Despite the paramount importance of adverse experience during early development on cognition and emotion in later stages of life, only a small number of studies have addressed this issue. In this symposium, four distinguished researchers from Hong Kong, Australia, and Korea will introduce the latest findings from their laboratories using rodents and human subjects. The audience in this symposium session is guaranteed to gain valuable insights into how stress and trauma during different stages of development modulate neurobehavioral systems in adolescence and adulthood.
Speaker | Affiliation | Title |
---|---|---|
Ying-Shing Chan | The University of Hong Kong | Balance of excitatory-inhibitory transmission in the developing vestibular nucleus tunes the brain circuitry for reflexes and spatial navigation |
Jee Hyun Kim | Deakin University | Chronic infancy or adolescent stress sex-dependently alters hypothalamic-pituitary-adrenal axis and extinction of conditioned fear |
June-Seek Choi | Korea University | Differential brain responses to chasing stress in the adolescent and adult brain |
Ji-Won Hur | Korea University | Neural correlates of vulnerability to nonsuicidal self-injury in response to childhood adversity |
Anthony Hannan / University of Melbourne
ModeratorAnthony Hannan / University of Melbourne
In this symposium, we bring together international speakers who are investigating novel aspects of RNA biology, in the context of neurodevelopment, experience-dependent plasticity, and other aspects of brain function, and dysfunction. The topics within transcriptomics and epitranscriptomics covered will include circular RNAs, small noncoding RNAs, long noncoding RNAs and RNA modifications. This symposium will share novel insights regarding the various ways in which RNA biology can mediate, and modulate, a wide range of processes within the developing and mature nervous system. Symposium attendees will be encouraged to consider RNA not only as medium for information transfer between DNA and protein levels, but also the wider realm of functional RNAs, and their key roles in brain development, function, and dysfunction.
Speaker | Affiliation | Title |
---|---|---|
Timothy Bredy | University of Queensland | RNA in Neuroscience |
Dan Ohtan Wang | New York University Abu Dhabi | Decoding m6A RNA modification signals at the neuronal synapses |
Anthony Hannan | University of Melbourne | Noncoding RNAs regulating brain function within and between generations |
Jung-Soo Han / Konkuk University
ChiHye Chung / Konkuk University
ModeratorJung-Soo Han / Konkuk University
Over the past ten years, there has been a significant surge in interest in the lateral habenula (LHb) due to recent discoveries highlighting its crucial role in controlling negatively driven behavior and its involvement in reward prediction as well as stress response. The LHb receives inputs from diverse limbic forebrain/basal ganglia structures, and targets essentially all midbrain neuromodulatory systems, including all the monoamine systems: so is anatomically well-positioned to integrate valence-based information to regulate various motivational and cognitive processes. We will discuss how emotional contagion promotes coping behaviors in conditions of heightened stress, and how this part of the emotional brain can determine social behaviors. We will expand the discussion to the role of the lateral habenula during the rewarding and aversive conditions in virtual reality as well as during conditioned inhibition, a fundamental component of associative learning. This symposium will shed light on the recent studies regarding the more complex function of the LHb.
Speaker | Affiliation | Title |
---|---|---|
Manuel Mameli | The University of Lausanne | Serotonin plasticity in habenula during emotional contagion protects from negative affective states |
ChiHye Chung | Konkuk University | Sociality regulation by cortico-habenula pathway under the stress |
HyungGoo Kim | Sungkyunkwan University | Diversity of lateral habenula neurons in reward and aversive processing |
Jung-soo Han | Konkuk University | The role of the lateral Habenula in conditioned inhibition |
Joung Hun Kim / Pohang University of Science and Technology
ModeratorJoung Hun Kim / Pohang University of Science and Technology
Repeated exposure to a drug of abuse induces neuronal and synaptic changes in the brain, leading to the compulsive seeking and use of drugs, and the loss of control over drug consumption. This addiction imposes a significant social and economic burden on the community. However, the processes through which addiction memory is established, perpetuated, and amplified remain unclear. Research on addiction memory utilizes various tools and concepts to elucidate the causal components of addictive states, understand the neural mechanisms involved, and develop effective therapeutic interventions. At this symposium, prominent researchers actively investigating addiction memory will present new findings that contribute to a deeper understanding of how molecular, cellular, and circuit changes in the nervous system dictate addiction memory and compulsive behavior.
Speaker | Affiliation | Title |
---|---|---|
Xiaoke Chen | Stanford University | Brain wide mapping of neural dynamics for drug seeking |
Anne Elizabeth West | Duke University | Chromatin regulation of brain-derived neurotrophic factor in cocaine craving |
Ja Wook Koo | Korea Brain Research Institute | Critical role of accumbal oligodendrocytes in cocaine seeking |
Tae-Kyung Kim | Pohang University of Science and Technology | Development of active enhancer-based stimulus-specific reporter system |
Won Chan Oh / University of Colorado
ModeratorWon Chan Oh / University of Colorado
Proper synaptic plasticity is essential for neural circuit function, and conversely, altered synaptic dynamics impair neuronal activity and are thought to underlie the pathology of brain disorders including ASDs. This idea is supported by the observation of increased synapse number in the frontal lobe in ASD brains. The prefrontal cortex (PFC) is a brain region associated with higher cognition that is shown to be disrupted in ASDs; yet, key questions remain unanswered concerning the neurobiological mechanisms that mediate the detrimental effects of altered synaptic and neuronal activity on PFC function. This symposium will bring together rising neuroscientists, leading experts in the synaptic and cellular basis of neuronal plasticity, to discuss the most recent advances in the field. A diverse group of 4 speakers will present recent findings on PFC function and dysfunction that are relevant to the major theme of this symposium.
Speaker | Affiliation | Title |
---|---|---|
Akiko Hayashi-Takagi | RIKEN | Linking neuronal activity in the prefrontal cortex to ASD symptoms: a reverse-translational assessment in ASD model mice |
Sho Yagishita | The University of Tokyo | Microglia-mediated noradrenergic gating of spine enlargement and learning in the medial prefrontal cortex |
Jung Ho Hyun | Daegu Gyeongbuk Institute of Science and Technology | Cellular learning rules for structural knowledge-based decision flexibility |
Won Chan Oh | University of Colorado | Synapse-level mechanisms of serotonin actions on neuronal plasticity in the prefrontal cortex |
Eun Jeong Lee / Ajou University
ModeratorEun Jeong Lee / Ajou University
Mikyoung Park / Korea Institute of Science and Technology
With the aging society, there is an increasing societal demand for research in the field of neuroscience, particularly in degenerative brain diseases. We would like to introduce female scientists actively contributing to various research methods in the diverse field of neurodegenerative diseases to KSBNS participants. Through this, we hope to encourage the influx of more women scientists into the field of neuroscience, introduce new perspectives in neurodegenerative disease research, and foster numerous collaborations.
Speaker | Affiliation | Title |
---|---|---|
Jee-Yin Ahn | Sungkyunkwan University | Functional loss of EBP1 in Alzheimer neurodegeneration and potent mouse model for sporadic AD |
Eun Jeong Lee | Ajou University | Body-brain interaction in developing Parkinson's disease |
Hyejin Park | Korea Advanced Institute of Science and Technology | A Novel Nuclease Contributing to Neurodegeneration in Parkinson’s Disease |
Ji-Yeun Hur | Ajou University | The modulation of γ-secretase in Alzheimer’s disease |
Joonyeol Lee / Sungkyunkwan University
Hyoung F. Kim / Seoul National University
ModeratorJoonyeol Lee / Sungkyunkwan University
This interdisciplinary symposium brings together experts in primate systems neuroscience and medical research. It explores primate intelligence's complexity and its implications for understanding the human brain, particularly in the context of brain diseases. Topics include natural intelligence in social settings, neural circuit mechanisms for efficient decision-making, and cutting-edge genetic techniques for modeling mental diseases in non-human primates. The symposium welcomes researchers, clinicians, students, and anyone interested in primate research, systems neuroscience, and brain disease studies. It offers a comprehensive overview of current research and fosters discussions on future directions in this field.
Speaker | Affiliation | Title |
---|---|---|
Kenichi Inoue | Kyoto University | Markerless motion capture system for social behavior analysis in normal and disease model primates |
Hyoung F. Kim | Seoul National University | Natural intelligence enables efficient information processing: extracting value from tactile and visual inputs facilitates effficiency in primates |
Soo Hyun Park | Korea Advanced Institute of Science and Technology | Studying dynamic visual processing in non-human primate model |
Youngjeon Lee | Korea Research Institute of Bioscience and Biotechnology | Research on brain disease models using non-human primates |
Chul-Kyu Park / Gachon University
Sun Wook Hwang / Korea University
ModeratorSeog Bae Oh (Seoul National University)
The 'Emerging Insights in Neuroimmunology and Pain' symposium explores the nexus between the nervous system and immune responses in pain. Focusing on how interleukins, microglia, and macrophages affect neuropathic pain, it integrates cutting-edge research on molecular pathways with clinical implications. Highlights include gender-specific neuroimmunological responses and novel therapeutic strategies. This interdisciplinary event appeals to researchers and clinicians, fostering dialogues and inspiring new treatments.
Speaker | Affiliation | Title |
---|---|---|
Temugin Berta | University of Cincinnati Medical Center | From viral infection to neuropathic pain: a closer look at STING activation in nociceptors and microglia |
Gang Chen | Nantong University | Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice |
Akio Wanaka | Nara Medical University | Dermal macrophages set the theshold for acute pain through tonic NGF signaling regulated by an SNX25-Nrf2 pathway |
Yong Ho Kim | Gachon University | Amyloid beta 1-42 modulates heat pain sensitivity in mature adult mice: unveiling the LRP1-SHP2 pathway in TRPV1 inhibition |
Jee Hyun Kim / Deakin University
ModeratorJee Hyun Kim / Deakin University
Kensuke Ikenaka / Osaka University
In this symposium, professor Tohda will open the symposium with her latest findings using Alzheimer’s disorder model mice that showed how phytochemical diosgenin (a constituent of yam) can reverse axon damage, change gene expression, and improve memory. This allowed a clinical trial of yam extract, which confirmed its benefit on cognition in people with mild Alzheimer’s disorder. Associate Professor Cheung will then follow with research showing the novel link between vascular injury and neuroinflammation, showing a potential causal pathomechanism of cognitive dysfunction associated with brain hypoxia due to vascular injury. This research offers new therapeutic targets to treat neurovascular conditions such as vascular dementia. Dr Senesi will then propose how the misfolding of proteins such as prion in Creutzfeldt-Jakob disease is a key mechanism that may apply across many neurological disorders including dementia. Such novel theory allows new therapeutic avenues to interfere with protein misfolding such as antibodies and antisense nucleotides to treat various neurological disorders. Lastly, Assistant Professor Ikenaka will present the novel discovery of lysosomal accumulation of KSBNS-APSN2024 SYMPOSIUM phosphatidylinositol-3-phosphate (PIP3) as an upstream pathomechanism to α-synuclein accumulation in Parkinson's disease across many model organisms as well as patient brain samples. This finding offers new therapeutic targets for a pre-emptive treatment for Parkinson’s disease. Professor Jee Hyun Kim will chair with Assistant Professor Ikenaka (co-chair) to lead an impartial discussion of the presented findings and potential questions.
Speaker | Affiliation | Title |
---|---|---|
Chihiro Tohda | University of Toyama | From basic study to clinical study for realizing new botanical medicines |
Christine Cheung | Nanyang Technological University | Chronic cerebral hypoperfusion induces endothelial dedifferentiation that leads to pathological venous remodeling |
Matteo Senesi | University of Melbourne | Prions as prototypical agents for neurodegenerative diseases: mechanisms, therapeutics and beyond |
Kensuke Ikenaka | Osaka University | Exploring treatments for Parkinson's disease through understanding the mechanisms of alpha-synuclein aggregation and propagation |
Dan Ohtan Wang / New York University Abu Dhabi
Chunyue Geoffrey LAU / City University of Hong Kong
ModeratorDan Ohtan Wang / New York University Abu Dhabi
Chunyue Geoffrey LAU / City University of Hong Kong
Brain development is a highly regulated phenomenon in which a variety of processes are involved, including synaptic plasticity, synapse formation and elimination, excitation-inhibition balance, transcriptional control, and translational control. This symposium aims to capture some of the latest findings in neural development and its malfunction that is implicated in disease states like epilepsy. We have brought together four internationally recognized speakers with wide-ranging research interests and expertise. Dr. Dan Ohtan WANG (NYU Abu Dhabi) is an expert in epigenetic regulation of synapse formation and will be a Co-Chair. Dr. Geoffrey LAU (City University of Hong Kong) will be a Co-Chair and speaker. He will speak about how a limbic region, anterior piriform (olfactory) cortex is involved in temporal lobe epilepsy. Dr. Zhuo HUANG (Peking University) will speak about epilepsy and how environmental cues can trigger seizure bouts in a phenomenon called conditioned seizure memory. Dr. Jacque IP (The Chinese University of Hong Kong) will speak about visual cortical development and its relationship with an epilepsy-related neurodevelopmental disorder. Dr. Kyung-Min NOH (EMBL Heidelberg) will speak about epigenetic regulation induced by BDNF and its implications in epilepsy. Together, the topics and methodology brought forth will illustrate our current understanding and innovation in neural development and epilepsy, making this symposium a timely and engaging one.
Speaker | Affiliation | Title |
---|---|---|
Chunyue Geoffrey LAU | City University of Hong Kong | Suppression of piriform cortex alters brain-wide dynamics and alleviates seizures in temporal lobe epilepsy |
Jacque Pak Kan IP | The Chinese University of Hong Kong | Cortical visual impairment: unraveling insights into neurodevelopment and epilepsy-related disorders |
Zhuo HUANG | Peking University | Termination of convulsion seizures by destabilizing and perturbing seizure memory engrams |
Kyung-Min NOH | European Molecular Biology Laboratory Heidelberg | Comparative genomics upon neuronal stimulation delineates neuronal regulatory elements linked to neuropsychiatric traits including epilepsy |
Eunha Kim / Korea University
ModeratorEunha Kim / Korea University
Neurodegenerative brain disorders present complex challenges that extend beyond the confines of the brain itself. Recent research suggests that the pathogenesis of neurodegenerative disorders is not solely confined to localized brain dysfunction but involves a dynamic interplay with various extra-cranial factors. This symposium aims to illuminate the intricate web of connections between the brain and external organs, with a special emphasis on the gut, immune system, and microbiome. Understanding the mechanisms operating both within the brain and in collaboration with peripheral organs is crucial for advancing our comprehension of these debilitating conditions. By delving into the molecular and cellular mechanisms within the brain and exploring the interconnectedness with peripheral organs, we aim to unravel the complex tapestry of neurodegenerative disorders.
Speaker | Affiliation | Title |
---|---|---|
Henning Ulrich | University of San Paulo | ATP signaling in Parkinson's disease |
Roberto de Pasquale | University of San Paulo | Crosstalk between caffeine consumption and neurodegenerative disorders |
Sangjune Kim | Chungbuk National University | Gut-to-brain propagation mouse model of Parkinson's disease |
Jung-Seok Kim | Weizmann Institute of Science | Colonization of non-cortical brain regions by monocyte-derived macrophages with a Dnmt3a mutation causes motor pathology |
Jong-Cheol Rah / Korea Brain Research Institute
ModeratorJong-Cheol Rah / Korea Brain Research Institute
Supported byIn the session ‘Sensory processing: Updates and storage of sensory information in prefrontal and parietal cortex’, we will explore the neural underpinnings of perception and short-term memory. In the session, we will explore the synergy of electrophysiology, calcium imaging and MRI in unraveling the mysteries of perception and short-term memory. This interdisciplinary approach will offer a comprehensive view of how senses are interpreted, stored, and manipulated. The session will foster collaboration among the scientists in the fields of cognitive, systems, and molecular neuroscience. Sensory information is processed in a dynamically regulated manner to successfully adapt to an ever-changing environment. During the session we will explore the dynamic network changes in response to rule-change, updated reward information, or simply during errors in short-term memory. We will explore the synergy of electrophysiology, calcium imaging and MRI in unraveling the mysteries of perception and short-term memory. This interdisciplinary approach will offer a comprehensive view of how senses are interpreted, stored, and manipulated. The session will foster collaboration among the scientists in the fields of cognitive, systems, and molecular neuroscience.
Speaker | Affiliation | Title |
---|---|---|
Daniel O'Connor | Johns Hopkins University | Rule-based modulation of a sensorimotor transformation |
Lukas Ian Schmitt | RIKEN | Thalamocortical networks dynamically encode statistical properties of sensory stimuli to enable perceptual inference |
Jong-Cheol Rah | Korea Brain Research Institute | Distributed encoding and opposite directional activities in the PPC during errors in short-term memory |
Won Mok Shim | Sungkyunkwan University | Spatially specific reward information in visual areas during closed-loop naturalistic interaction |
Thomas McHugh / RIKEN
Min-Ho Nam / Korea Institute of Science and Technology
ModeratorThomas McHugh / RIKEN
Min-Ho Nam / Korea Institute of Science and Technology
Our quest to understand memory builds on fundamental work addressing the molecular, synaptic, physiological and behavioral processes engaged during learning. Over the last decade rapid technological advancements on all these level, harnessing progress in machine learning, high-density imaging and recording, high-throughput genomics and proteomics and genetic tools for circuit characterization and manipulation, has accelerated progress in the field and uncovered new and surprising connections between levels of investigation. This session will showcase the application of these emerging approaches, including large-scale in vivo electrophysiology, whole-brain synaptome mapping, and virtual reality based brain-machine interfaces, to long-standing questions of how mammalian brains encode and use memories, as well as inspire researchers across all fields to harness these tools in their own work.
Speaker | Affiliation | Title |
---|---|---|
Thomas McHugh | RIKEN | Non-canonical hippocampal memory circuits |
Timothy Harris | Johns Hopkins University | Neuropixels 2.0: a miniaturized high-density probe for stable, long-term brain recordings |
Seth Grant | The University of Edinburgh | Synapse diversity and the dynamic synaptome architecture |
Albert Lee | Harvard University | Volitional activation of remote place representations with a hippocampal brain–machine interface |
Sunmo Oh / Bio-Medical Science Co., Ltd.
Hyungmin Im / CHAYON Laboratories, Inc.
ModeratorSeungbok Lee / Seoul National University
The suggested symposium theme, "Integrative Insights into Neurobiology: From Physiological Neural Models to Neurodegenerative Diseases and Drug Discovery," encompasses a comprehensive exploration of various facets of neuroscience research. The first topic emphasizes the use of physiological neural model systems to delve into studies related to brain development, neuronal maturation, and neuroinflammation. The second topic shifts the focus to utilizing microplate readers in unraveling neurodegenerative diseases, specifically highlighting prion research and protein aggregation. Finally, the third topic underscores the power of in vitro systems using human induced pluripotent stem cell (iPSC) models for advancing drug discovery. This amalgamation of diverse themes aims to encompass the broad spectrum of neuroscience while emphasizing practical and applicable research domains.
Speaker | Affiliation | Title |
---|---|---|
Jason Hamlin | STEMCELL Technologies, Inc. | Using physiological neural model systems to study neurodevelopment, neuronal maturation and neuroinflammation |
Joko Logis | BMG LABTECH | Uncovering neurodegenerative diseases using microplate readers: prion research and protein aggregation |
Ko Zushida | FUJIFILM Cellular Dynamics, Inc. | A powerful in vitro system using human iPSC models enables facilitating drug discovery |
Ain Chung / Korea Advanced Institute of Science and Technology
Jaekyung Kim / Korea Advanced Institute of Science and Technology
ModeratorMin Whan Jung / Korea Advanced Institute of Science and Technology
The symposium unveils novel perspectives on information storage and utilization, framing them as highly dynamic information processing phenomena. The plasticity of neural networks enables long-term stored information to enhance cognitive abilities, and the decision-making process intricately integrates current sensory input with stored value information. The symposium delves into the intricate information integration processes of cognition at the neural network level and aims to shed light on how these dynamic cognitive processes are represented and stored in the brain. Topics include the influence of neural activity during sleep on memory formation, the role of neuroplasticity in enhancing cognitive abilities, and the complex neural integration of olfactory and auditory input in decision-making. Through the symposium, attendees will gain insights into the cutting-edge research conducted by emerging neuroscientists who are actively investigating the neural correlates of cognition.
Speaker | Affiliation | Title |
---|---|---|
Jeongjin Kim | Korea Institute of Science and Technology | Dynamic neural representation for movement-dependent auditory decision making |
David M. Schneider | New York University | Cortical error detection enables skilled acoustic behaviors |
Jaekyung Kim | Korea Advanced Institute of Science and Technology | Exploring circuit dynamics during sleep and neural representations in motor learning |
Ain Chung | Korea Advanced Institute of Science and Technology | Hippocampal circuit mechanisms underlying social information processing enhancement |
Seung-Hee Lee / Korea Advanced Institute of Science and Technology
Co-organizerInstitute for Basic Science (IBS)
Seung-Hee Lee / Korea Advanced Institute of Science and Technology
Autism spectrum disorder (ASD) is a neurodevelopmental disorder marked by deficits in reciprocal social communication and the presence of restricted and repetitive patterns of behavior. It is highly heritable but regarded as a spectrum disorder, co-occurring with other diverse conditions. This symposium aims to present the most recent advancements in understanding neural circuit mechanisms governing pathological conditions in ASD. Esteemed neuroscientists will be featured in this symposium, encompassing both male and female speakers from the United States, Japan, and Korea. Each presenter in this symposium has employed state-of-the-art methodologies to delineate critical neural circuits underlying social deficits, sleep disturbances, memory deficits, and sensory dysfunctions in ASD mouse models. The symposium anticipates drawing a considerable audience interested in new aspects of brain dysfunctions in ASD.
Speaker | Affiliation | Title |
---|---|---|
Toru Takumi | Kobe University | Social neural networks in autism |
Shinjae Chung | University of Pennsylvania | Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism |
Franz Weber | University of Pennsylvania | Cortical regulation of REM sleep and its dysfunction in autism |
Yong-Seok Lee | Seoul National University | Sex-Specific Sensory and Circuit Deficits in Mouse Models of Neurodevelopmental Disorders |
Scientific Program Committees of the KSBNS and AKN
ModeratorSeonil Kim / Colorado State University
Sang Ki Park / Pohang University of Science and Technology
Neurodevelopmental disorders are types of disorder that alters neurological development, causing difficulties in a wide range of brain functions. Children with neurodevelopmental disorders can experience difficulties with language and speech, motor skills, behavior, memory, learning, or other neurological functions. Causes are heterogeneous ranging from social deprivation, genetic and metabolic diseases, immune disorders, infectious diseases, nutritional factors, physical trauma, and toxic and environmental factors. However, our current knowledge of neurobiological mechanisms underlying neurodevelopmental disorders is far from complete. The current symposium aims to bring attention to research on neurobiological mechanisms of neurodevelopmental disorders.
Speaker | Affiliation | Title |
---|---|---|
Jinju Han | Korea Advanced Institute of Science and Technology | AGO1-LIN28A-REELIN regulatory axis in brain development and disease: association of AGO1 with autism spectrum disorder |
Seonil Kim | Colorado State University | The autism-associated loss of δ-catenin functions disrupts social behavior |
Sang Ki Park | Pohang University of Science and Technology | Perturbed cell fate decision by a schizophrenia-associated AS3MT isoform during corticogenesis |
Hyun Kyoung Lee | Baylor College of Medicine | Deciphering mechanisms of perinatal white matter injury-induced neuropsychiatric outcome |
Wuhyun Koh / Institute for Basic Science
C. Justin Lee / Institute for Basic Science
Co-organizerInstitute for Basic Science (IBS)
Wuhyun Koh / Institute for Basic Science
The concept of "brain plasticity" often conjures images of synaptic connections between neurons, both in the minds of neuroscientists and the general public. Our goal is to expand beyond this traditional viewpoint by proposing a symposium focused on the plasticity of astrocytes surrounding synapses. This session aims to highlight the significance of morphological plasticity—termed here as morphoplasticity—and explore its role in influencing cognitive functions within the brain.
Speaker | Affiliation | Title |
---|---|---|
Wuhyun Koh | Institute for Basic Science | Ank2 in Hippocampal Astrocyte Morphogenesis and Memory Formation |
Ruotian Jiang | Sichuan University | Astrocyte morphological remodeling: at the synapse and beyond |
Baptiste Lacoste | University of Ottawa | Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation |
Sabina Berretta | Harvard University | Collaborations among peers: astrocyte-neuron interactions in plasticity and brain disorders |
Taegon Kim / Korea Institute of Science and Technology
ModeratorTaegon Kim / Korea Institute of Science and Technology
Although modern neuroscience reveals the mechanism of specific brain functions and recent artificial neural network models demonstrate powerful performance on specific tasks, understanding how neural networks whether implemented naturally in the brain or artificially could generate such functions have been considered still enigmatic. Thus, this symposium session will focus on the effort to find out the general principles underlying how neural networks work in computational neuroscience. The topics in this symposium are selected and organized to promote in-depth discussions from a variety of perspectives, ranging from the conventional dynamics of neurons and synapses to the recently highlighted properties of neural networks, such as modulation or information processing cost.
Speaker | Affiliation | Title |
---|---|---|
Mark van Rossum | University of Nottingham | Energy efficient learning in biological and artificial neural networks |
Louis Kang | RIKEN | Computational demands can influence seizure susceptibility in recurrent neural networks |
Hyojin Bae | Seoul National University | A normative principle governing memory transfer in cerebellar motor learning |
Taegon Kim | Korea Institute of Science and Technology | Dependence of functional diversification by modulatory neurotransmitters on the architecture of neural networks |